Your state of mindSide effects, concern about risks, fatigue, social isolation and the rare nature of myeloproliferative neoplasms (MPNs) can all take a toll. Some people with MPNs take their diagnosis in their stride. But all these disorders, whether essential thrombocythaemia (ET), polycythaemia vera (PV) or myelofibrosis (MF), come with some challenges. It’s hardly surprising that people with MPNs, just like people with other illnesses, at times find themselves feeling demoralised, helpless or pessimistic. These feelings, which are common in long-term illnesses, are not only distressing but can also hold you back because they can have an impact on behaviour. Fortunately, there are many things that can be done to help you maintain a healthy state of mind.