A vlogcast with Prof Claire Harrison, Guy’s & St Thomas’ Hospital, London and Nona Baker, Co-Chair MPN Voice.
This vlogcast highlights key developments in the MPN (Myeloproliferative Neoplasms) field, shared by Professor Claire Harrison, focusing on the American Society of Hematology (ASH) conference and MPN Voice’s 2025 achievements. Key points include:
- ASH Conference Updates:
- Advances in calreticulin (CALR) therapies, particularly a monoclonal antibody showing great promise for patients with ET (Essential Thrombocythaemia) and myelofibrosis, with good tolerability and positive effects on platelet count, spleen size, and anaemia.
- Updates on JAK inhibitors and the potential for targeted therapies for MPNs with the MPL mutation (affecting 5-10% of patients) coming in 2026.
- Ongoing studies on interferon and combination therapies, like momelotinib and pelabresib, showing continued patient benefits and safety.
- MPN Voice’s 2025 Achievements:
- Collaboration with Blood Cancer UK to address the interferon shortage in the UK and ensure access to treatments.
- Expansion of the MPN Voice app and integration of wearable devices, with real-time patient data helping to shape future clinical trials.
- Successful patients’ forums in various locations in the UK and Ireland, including an increased number of clinicians and researchers participating the Living with MPNs Day in London.
- Continued community engagement, including the sad farewell to Maz, who has been instrumental in the forums, and the welcoming of Debbie to the team.
- Announcement of a northern UK patient day in York on 4th July 2026.
- Looking Ahead:
- Excitement for 2026, with more scientific updates, ongoing app data collection, and continued advocacy efforts.
- Strategic review of MPN Voice, with plans to expand its reach and improve collaborations with other organizations.
- Refreshed website and ongoing requests for community input on future initiatives.
The vlog ends with wishes for peace, goodwill, and good health over the festive season from Claire and Nona.
We hope that you enjoyed this conversation, please send feedback and any questions to info@mpnvoice.org.uk. If you have any suggestions for future conversations, please email us.
We would like to thank Prof Harrison for taking part in this conversation with Nona.
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